Photo by Isa

Search Hotels in Santa Ana, Panama City

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Santa Ana, Panama City

Casco View Apartments

3.0 star property
9.2 out of 10, Wonderful, (42)
"I liked the buildings quietness and modern style."
The price is 644 kr.
includes taxes & fees
21 Aug - 22 Aug
Casco View Apartments

ART CASCO The Hotel

2.0 star property
6.8 out of 10, (6)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
ART CASCO The Hotel

Hotel República

2.0 star property
6.6 out of 10, (171)
"The wifi is strong enough to use for work. "
Hotel República

Hostal La Cigarra

2.5 star property
7.6 out of 10, Good, (50)
"Great location to walk around the casco! Street parking available for free! Prices are really affordable! Staff was really helpful "
Hostal La Cigarra

Hotel Riazor

3.0 star property
3.8 out of 10, (10)
"Rough neighborhood "
Hotel Riazor

La Manzana by Wynwood House

3.5 star property
6.8 out of 10, (12)
"Great hotel. Very close to Casco viejo"
The price is 505 kr.
includes taxes & fees
5 Aug - 6 Aug
La Manzana by Wynwood House

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
The price is 1.012 kr.
includes taxes & fees
18 Aug - 19 Aug
Room-sofa Bed Stay Rooftop Pool & Gym, A

Casa Quijano 06 By Wynwood House

4.0 star property
9.4 out of 10, Exceptional, (3)
"The apartment itself was very nice, very spacious, clean, newer furniture. Just know it’s on the third floor and there is no elevator. I didn’t see a sign on the building so it was a bit tricky to figure out which door to go to after being dropped off by the Uber. Email communication from property with building entry code and picture of the property was helpful. There are two balconies but all you really see is the apartment immediately in front of you, and so just know people can see you if you...
The price is 765 kr.
includes taxes & fees
10 Aug - 11 Aug
Casa Quijano 06 By Wynwood House

w Charming 1BR in Santa Ana s Best Area

2.0 star property
The price is 688 kr.
includes taxes & fees
17 Aug - 18 Aug
w Charming 1BR in Santa Ana s Best Area

Crowne Plaza Panama Airport by IHG

4.0 star property
8.4 out of 10, Very good, (2178)
"Great hotel"
The price is 779 kr.
includes taxes & fees
1 Sept - 2 Sept
Crowne Plaza Panama Airport by IHG

Central Hotel Panama Casco Viejo

4.0 star property
9.0 out of 10, Wonderful, (961)
"Love the location and the restaurant inside the hotel was phenomenal."
The price is 1.447 kr.
includes taxes & fees
8 Aug - 9 Aug
Central Hotel Panama Casco Viejo

The Westin Playa Bonita Panama

5.0 star property
8.0 out of 10, Very good, (1005)
"Very nice hotel and servise excellent."
The price is 1.091 kr.
includes taxes & fees
13 Aug - 14 Aug
The Westin Playa Bonita Panama

Riande Aeropuerto Hotel & Casino

4.0 star property
8.4 out of 10, Very good, (1889)
"Great place to stay while overnight in Panama"
The price is 1.028 kr.
includes taxes & fees
17 Aug - 18 Aug
Riande Aeropuerto Hotel & Casino

TRYP by Wyndham Panamá Centro

3.5 star property
9.0 out of 10, Wonderful, (1003)
"Great location "
The price is 638 kr.
includes taxes & fees
31 Aug - 1 Sept
TRYP by Wyndham Panamá Centro

Hospedium Princess Hotel Panama

3.5 star property
7.6 out of 10, Good, (572)
"Nice clean ambiance"
The price is 307 kr.
includes taxes & fees
10 Aug - 11 Aug
Hospedium Princess Hotel Panama

Megapolis Hotel Panamá

4.5 star property
8.4 out of 10, Very good, (997)
"Lovely hotel "
The price is 900 kr.
includes taxes & fees
24 Aug - 25 Aug
Megapolis Hotel Panamá

Hotel Coral Suites

3.5 star property
9.0 out of 10, Wonderful, (1002)
"Nice Hotel "
The price is 491 kr.
includes taxes & fees
5 Aug - 6 Aug
Hotel Coral Suites

Principe Hotel and Suites

3.0 star property
9.0 out of 10, Wonderful, (1422)
"Great Hotell , super location safe "
The price is 414 kr.
includes taxes & fees
5 Aug - 6 Aug
Principe Hotel and Suites

La Concordia Boutique Hotel

4.0 star property
9.4 out of 10, Exceptional, (176)
"The rooms were beautiful "
The price is 1.222 kr.
includes taxes & fees
1 Sept - 2 Sept
La Concordia Boutique Hotel

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4140)
"I had a great stay there"
The price is 764 kr.
includes taxes & fees
25 Aug - 26 Aug
Hotel Riu Plaza Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
Casco Viejo map

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Bella Vista map

Bella Vista

1 out of top 10 points of interest in this area

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo map

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco map

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla map

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?

Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.

How many hotels can I expect to find in Santa Ana?

Expedia has 101 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.

What is there to do in this Panama City neighbourhood?

If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.